Drug interactions
Diflunisal + Vadadustat
Severity: Moderate
Diflunisal and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal may inhibit renal and hepatic OAT1/OAT3 transporters, which could raise vadadustat exposure. This may lead to an excessive hemoglobin rise and more adverse reactions.
What this interaction means in plain words
Diflunisal and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of OAT1/OAT3-mediated transport reduces vadadustat clearance.
What to do
Monitor hemoglobin closely and adjust the vadadustat dose per labeling if the rise is too rapid. Consider another analgesic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Diflunisal with Vadadustat?
MediHelp rates the interaction as moderate. Diflunisal and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal may inhibit renal and hepatic OAT1/OAT3 transporters, which could raise vadadustat exposure. This may lead to an excessive hemoglobin rise and more adverse reactions.
How serious is the interaction between Diflunisal and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin closely and adjust the vadadustat dose per labeling if the rise is too rapid. Consider another analgesic if feasible.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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