Drug interactions
Diflunisal + Vortioxetine
Severity: Moderate
Diflunisal and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine, like other serotonergic antidepressants, may impair platelet function, and with an NSAID such as diflunisal the risk of bleeding is increased, particularly in the gastrointestinal tract.
What this interaction means in plain words
Diflunisal and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Vortioxetine belongs to Central Nervous System.
Why it happens
Reduced platelet serotonin uptake impairs aggregation, adding to NSAID antiplatelet and mucosal effects.
What to do
Monitor for signs of bleeding and consider gastroprotection in high-risk patients. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Diflunisal with Vortioxetine?
MediHelp rates the interaction as moderate. Diflunisal and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine, like other serotonergic antidepressants, may impair platelet function, and with an NSAID such as diflunisal the risk of bleeding is increased, particularly in the gastrointestinal tract.
How serious is the interaction between Diflunisal and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider gastroprotection in high-risk patients. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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