Drug interactions
Digoxin + Dulaglutide
Severity: Minor
Digoxin and Dulaglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide delays gastric emptying, which could alter the rate of absorption of oral digoxin. Clinical studies of related GLP-1 agents show little effect on overall digoxin exposure.
What this interaction means in plain words
Digoxin and Dulaglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Dulaglutide belongs to Endocrine.
Why it happens
Delayed gastric emptying may modestly slow the rate of digoxin absorption.
What to do
No dose change is generally needed; monitor digoxin levels if gastrointestinal effects such as vomiting occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Dulaglutide
Frequently asked questions
Can I take Digoxin with Dulaglutide?
MediHelp rates the interaction as minor. Digoxin and Dulaglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dulaglutide delays gastric emptying, which could alter the rate of absorption of oral digoxin. Clinical studies of related GLP-1 agents show little effect on overall digoxin exposure.
How serious is the interaction between Digoxin and Dulaglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor digoxin levels if gastrointestinal effects such as vomiting occur.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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