Drug interactions
Digoxin + Etodolac
Severity: Moderate
Digoxin and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can impair renal function and may raise digoxin concentrations, potentially leading to digoxin toxicity. Heart failure may also be exacerbated by fluid retention.
What this interaction means in plain words
Digoxin and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
Reduced renal prostaglandin-dependent perfusion lowers digoxin renal clearance, increasing serum levels.
What to do
Monitor serum digoxin concentration, renal function and potassium when etodolac is started or changed. Reduce the digoxin dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Etodolac?
MediHelp rates the interaction as moderate. Digoxin and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can impair renal function and may raise digoxin concentrations, potentially leading to digoxin toxicity. Heart failure may also be exacerbated by fluid retention.
How serious is the interaction between Digoxin and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentration, renal function and potassium when etodolac is started or changed. Reduce the digoxin dose if levels rise.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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