Drug interactions
Digoxin + Famotidine
Severity: Minor
Digoxin and Famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine may slightly alter digoxin absorption by changing gastric pH. Significant clinical changes are uncommon.
What this interaction means in plain words
Digoxin and Famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Famotidine belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH may modestly enhance digoxin bioavailability.
What to do
No routine action; consider checking digoxin level if toxicity is suspected after starting or stopping famotidine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Famotidine
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Famotidine?
MediHelp rates the interaction as minor. Digoxin and Famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine may slightly alter digoxin absorption by changing gastric pH. Significant clinical changes are uncommon.
How serious is the interaction between Digoxin and Famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action; consider checking digoxin level if toxicity is suspected after starting or stopping famotidine.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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