Drug interactions
Digoxin + Fosinopril-hydrochlorothiazide
Severity: Moderate
Digoxin and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-induced hypokalemia and hypomagnesemia sensitize the myocardium to digoxin and can precipitate arrhythmias and digoxin toxicity. ACE inhibitors may also modestly raise digoxin levels, and renal function changes can further alter exposure.
What this interaction means in plain words
Digoxin and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Diuretic-induced potassium and magnesium depletion increases digoxin sensitivity, with possible small reduction in digoxin renal clearance from ACE inhibition.
What to do
Monitor serum potassium, magnesium and renal function regularly and keep potassium in the normal range. Check digoxin level and ECG if toxicity symptoms appear or therapy changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Digoxin and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-induced hypokalemia and hypomagnesemia sensitize the myocardium to digoxin and can precipitate arrhythmias and digoxin toxicity. ACE inhibitors may also modestly raise digoxin levels, and renal function changes can further alter exposure.
How serious is the interaction between Digoxin and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium and renal function regularly and keep potassium in the normal range. Check digoxin level and ECG if toxicity symptoms appear or therapy changes.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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