Drug interactions
Digoxin + Fostemsavir
Severity: Minor
Digoxin and Fostemsavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active moiety temsavir inhibits OATP1B1/3 and BCRP, but digoxin is not mainly handled by these transporters. A clinically meaningful change in digoxin exposure is therefore not established and likely small.
What this interaction means in plain words
Digoxin and Fostemsavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Fostemsavir belongs to Anti Virals.
Why it happens
Temsavir inhibits drug transporters, but its effect on digoxin disposition is not well established.
What to do
No routine dose change is needed. Monitor digoxin concentrations and for toxicity when starting fostemsavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Digoxin with Fostemsavir?
MediHelp rates the interaction as minor. Digoxin and Fostemsavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostemsavir's active moiety temsavir inhibits OATP1B1/3 and BCRP, but digoxin is not mainly handled by these transporters. A clinically meaningful change in digoxin exposure is therefore not established and likely small.
How serious is the interaction between Digoxin and Fostemsavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor digoxin concentrations and for toxicity when starting fostemsavir.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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