Drug interactions
Digoxin + Glycopyrronium
Severity: Moderate
Digoxin and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Slowing of gastrointestinal transit by antimuscarinics can increase absorption of slowly dissolving digoxin tablets, modestly raising digoxin levels. The effect is generally small, but toxicity is possible in patients on a narrow margin.
What this interaction means in plain words
Digoxin and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Glycopyrronium belongs to Respiratory.
Why it happens
Reduced gastrointestinal motility prolongs digoxin dissolution and absorption time.
What to do
Monitor for signs of digoxin toxicity and check serum digoxin concentration if glycopyrronium is started or stopped in a patient on stable therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Glycopyrronium + Potassium chloride Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Glycopyrronium?
MediHelp rates the interaction as moderate. Digoxin and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Slowing of gastrointestinal transit by antimuscarinics can increase absorption of slowly dissolving digoxin tablets, modestly raising digoxin levels. The effect is generally small, but toxicity is possible in patients on a narrow margin.
How serious is the interaction between Digoxin and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of digoxin toxicity and check serum digoxin concentration if glycopyrronium is started or stopped in a patient on stable therapy.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Potassium chloride, Abobotulinumtoxina. The full list is on the Glycopyrronium page.
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