Drug interactions
Digoxin + Ipratropium-salbutamol
Severity: Moderate
Digoxin and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salbutamol can lower serum potassium and may modestly reduce digoxin levels, and hypokalemia increases the risk of digoxin toxicity and arrhythmias. Both drugs can also cause tachyarrhythmias.
What this interaction means in plain words
Digoxin and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Beta-2 agonist-induced hypokalemia sensitizes the myocardium to digoxin, with possible small changes in digoxin concentrations.
What to do
Monitor serum potassium and digoxin levels, especially with high-dose or nebulized salbutamol. Correct hypokalemia and watch for arrhythmias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Digoxin and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salbutamol can lower serum potassium and may modestly reduce digoxin levels, and hypokalemia increases the risk of digoxin toxicity and arrhythmias. Both drugs can also cause tachyarrhythmias.
How serious is the interaction between Digoxin and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and digoxin levels, especially with high-dose or nebulized salbutamol. Correct hypokalemia and watch for arrhythmias.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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