Drug interactions
Digoxin + Isoproterenol
Severity: Moderate
Digoxin and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol is a potent beta-agonist that increases heart rate and automaticity and can lower serum potassium. With digoxin it may increase the risk of tachyarrhythmias and ventricular ectopy.
What this interaction means in plain words
Digoxin and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Isoproterenol belongs to Respiratory.
Why it happens
Additive proarrhythmic effects through beta-adrenergic stimulation and potassium shift, increasing sensitivity to digoxin.
What to do
Use continuous ECG monitoring and check serum potassium during isoproterenol therapy in digitalized patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Digoxin with Isoproterenol?
MediHelp rates the interaction as moderate. Digoxin and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol is a potent beta-agonist that increases heart rate and automaticity and can lower serum potassium. With digoxin it may increase the risk of tachyarrhythmias and ventricular ectopy.
How serious is the interaction between Digoxin and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use continuous ECG monitoring and check serum potassium during isoproterenol therapy in digitalized patients.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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