Drug interactions
Digoxin + Ketoprofen
Severity: Moderate
Digoxin and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce renal function and thereby raise digoxin concentrations, increasing the risk of digoxin toxicity. This is most relevant in older patients or those with renal impairment or heart failure.
What this interaction means in plain words
Digoxin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal prostaglandins and glomerular filtration decreases digoxin renal clearance.
What to do
Monitor serum digoxin level, renal function and potassium when starting or stopping ketoprofen, and adjust the digoxin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Ketoprofen?
MediHelp rates the interaction as moderate. Digoxin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce renal function and thereby raise digoxin concentrations, increasing the risk of digoxin toxicity. This is most relevant in older patients or those with renal impairment or heart failure.
How serious is the interaction between Digoxin and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin level, renal function and potassium when starting or stopping ketoprofen, and adjust the digoxin dose as needed.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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