Drug interactions
Digoxin + Leniolisib
Severity: Moderate
Digoxin and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1 and OATP1B3 transporters, and this may raise systemic exposure to substrates of these transporters. Digoxin has a narrow therapeutic index, so any rise in exposure could increase the risk of digoxin toxicity such as arrhythmia, nausea and visual disturbance.
What this interaction means in plain words
Digoxin and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Leniolisib belongs to Miscellaneous.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake transport by leniolisib may reduce digoxin clearance, although digoxin is only a minor OATP substrate.
What to do
Monitor digoxin serum concentrations and heart rate/ECG when starting or stopping leniolisib. Reduce the digoxin dose if concentrations rise or signs of toxicity appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Digoxin with Leniolisib?
MediHelp rates the interaction as moderate. Digoxin and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits OATP1B1 and OATP1B3 transporters, and this may raise systemic exposure to substrates of these transporters. Digoxin has a narrow therapeutic index, so any rise in exposure could increase the risk of digoxin toxicity such as arrhythmia, nausea and visual disturbance.
How serious is the interaction between Digoxin and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin serum concentrations and heart rate/ECG when starting or stopping leniolisib. Reduce the digoxin dose if concentrations rise or signs of toxicity appear.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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