Drug interactions
Digoxin + Levofloxacin
Severity: Minor
Digoxin and Levofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin has little effect on digoxin in most patients, but a modest rise in digoxin levels has been described, possibly through P-glycoprotein effects. Digoxin toxicity could therefore occur in a vulnerable patient, such as one with renal impairment.
What this interaction means in plain words
Digoxin and Levofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Levofloxacin belongs to Anti Bacterial.
Why it happens
Possible inhibition of P-glycoprotein-mediated digoxin efflux, increasing absorption and reducing clearance; the effect is small and inconsistent.
What to do
Monitor for signs of digoxin toxicity and check a digoxin level if symptoms or renal impairment are present. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Digoxin and Levofloxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Levofloxacin?
MediHelp rates the interaction as minor. Digoxin and Levofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levofloxacin has little effect on digoxin in most patients, but a modest rise in digoxin levels has been described, possibly through P-glycoprotein effects. Digoxin toxicity could therefore occur in a vulnerable patient, such as one with renal impairment.
How serious is the interaction between Digoxin and Levofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of digoxin toxicity and check a digoxin level if symptoms or renal impairment are present. No routine dose change is needed.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
