Drug interactions
Digoxin + Levothyroxine
Severity: Moderate
Digoxin and Levothyroxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Correcting hypothyroidism with levothyroxine increases digoxin clearance and volume of distribution, so a previously stable digoxin dose may become less effective. Conversely, as patients become euthyroid, digoxin requirements typically rise.
What this interaction means in plain words
Digoxin and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Levothyroxine belongs to Endocrine.
Why it happens
Thyroid hormone replacement raises metabolic rate and renal clearance of digoxin, lowering serum concentrations.
What to do
Monitor digoxin levels and clinical response when levothyroxine is started or its dose changed, and adjust the digoxin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Levothyroxine
Frequently asked questions
Can I take Digoxin with Levothyroxine?
MediHelp rates the interaction as moderate. Digoxin and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Correcting hypothyroidism with levothyroxine increases digoxin clearance and volume of distribution, so a previously stable digoxin dose may become less effective. Conversely, as patients become euthyroid, digoxin requirements typically rise.
How serious is the interaction between Digoxin and Levothyroxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin levels and clinical response when levothyroxine is started or its dose changed, and adjust the digoxin dose accordingly.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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