Drug interactions
Digoxin + Linagliptin-metformin
Severity: Minor
Digoxin and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metformin and digoxin are both cleared in part by renal tubular secretion, so they may compete and modestly alter each other's levels. Clinically significant changes are uncommon, but digoxin has a narrow therapeutic index.
What this interaction means in plain words
Digoxin and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Linagliptin-metformin belongs to Endocrine.
Why it happens
Possible competition for renal tubular cationic transport.
What to do
Monitor serum digoxin concentration and clinical signs of toxicity when starting or stopping metformin, especially in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Linagliptin-metformin?
MediHelp rates the interaction as minor. Digoxin and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metformin and digoxin are both cleared in part by renal tubular secretion, so they may compete and modestly alter each other's levels. Clinically significant changes are uncommon, but digoxin has a narrow therapeutic index.
How serious is the interaction between Digoxin and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentration and clinical signs of toxicity when starting or stopping metformin, especially in renal impairment.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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