Drug interactions
Digoxin + Memantine-donepezil
Severity: Moderate
Digoxin and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Digoxin and memantine are both handled by the kidney, but a clinically meaningful pharmacokinetic interaction is not well established. Separately, donepezil can slow heart rate and cause bradycardia or heart block, which may add to the effects of digoxin on conduction.
What this interaction means in plain words
Digoxin and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive vagotonic effects on the AV node from donepezil and digoxin; a renal tubular competition effect with memantine is theoretical.
What to do
Monitor heart rate and ECG for bradycardia or AV block, and check digoxin levels if toxicity is suspected. Counsel patients to report syncope or dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Memantine-donepezil?
MediHelp rates the interaction as moderate. Digoxin and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Digoxin and memantine are both handled by the kidney, but a clinically meaningful pharmacokinetic interaction is not well established. Separately, donepezil can slow heart rate and cause bradycardia or heart block, which may add to the effects of digoxin on conduction.
How serious is the interaction between Digoxin and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG for bradycardia or AV block, and check digoxin levels if toxicity is suspected. Counsel patients to report syncope or dizziness.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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