Drug interactions
Digoxin + Nadolol
Severity: Moderate
Digoxin and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs slow sinus rate and AV nodal conduction, so combination can cause symptomatic bradycardia or heart block. It is often used deliberately for rate control but needs careful surveillance. Nadolol is renally cleared, so renal impairment amplifies the risk.
What this interaction means in plain words
Digoxin and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic suppression of sinoatrial and AV nodal function.
What to do
Monitor heart rate, ECG and PR interval, and adjust doses if bradycardia or AV block occurs; check renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Nadolol
Frequently asked questions
Can I take Digoxin with Nadolol?
MediHelp rates the interaction as moderate. Digoxin and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs slow sinus rate and AV nodal conduction, so combination can cause symptomatic bradycardia or heart block. It is often used deliberately for rate control but needs careful surveillance. Nadolol is renally cleared, so renal impairment amplifies the risk.
How serious is the interaction between Digoxin and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and PR interval, and adjust doses if bradycardia or AV block occurs; check renal function.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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