Drug interactions
Digoxin + Nebivolol
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive AV-nodal suppression may cause bradycardia or heart block.
Mechanism of action
Pharmacodynamic: combined negative chronotropic/dromotropic effects from beta-blockade and digoxin.
Clinical management
Monitor heart rate and ECG, particularly during initiation or dose adjustments; reduce doses if excessive bradycardia or AV block occurs; avoid adding other AV-nodal–blocking drugs.
Drug reference
References
- BYSTOLIC (nebivolol) Prescribing Information — FDA Label
- Digoxin: Drug information — UpToDate
Frequently asked questions
Can I take Digoxin with Nebivolol?
The interaction is rated: Moderate. Additive AV-nodal suppression may cause bradycardia or heart block.
How serious is the interaction between Digoxin and Nebivolol?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between Digoxin and Nebivolol managed?
Monitor heart rate and ECG, particularly during initiation or dose adjustments; reduce doses if excessive bradycardia or AV block occurs; avoid adding other AV-nodal–blocking drugs.
Why do Digoxin and Nebivolol interact?
Pharmacodynamic: combined negative chronotropic/dromotropic effects from beta-blockade and digoxin.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.