Drug interactions
Digoxin + Neratinib
Severity: Moderate
Digoxin and Neratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neratinib inhibits P-glycoprotein and can increase digoxin exposure. Because digoxin has a narrow therapeutic index, this may cause toxicity.
What this interaction means in plain words
Digoxin and Neratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Neratinib belongs to Oncology.
Why it happens
P-glycoprotein inhibition decreases digoxin efflux and renal elimination.
What to do
Monitor digoxin concentrations and reduce the digoxin dose as needed when neratinib is started; watch for signs of toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Neratinib
- Amiodarone + Neratinib Major
- Amobarbital + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Bosentan + Neratinib Major
- Carbamazepine + Neratinib Major
Frequently asked questions
Can I take Digoxin with Neratinib?
MediHelp rates the interaction as moderate. Digoxin and Neratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neratinib inhibits P-glycoprotein and can increase digoxin exposure. Because digoxin has a narrow therapeutic index, this may cause toxicity.
How serious is the interaction between Digoxin and Neratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations and reduce the digoxin dose as needed when neratinib is started; watch for signs of toxicity.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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