Drug interactions
Digoxin + Nicardipine
Severity: Moderate
Digoxin and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine can raise serum digoxin concentrations in some patients, with a risk of digoxin toxicity such as nausea, arrhythmias and visual disturbances. The effect is variable and generally modest.
What this interaction means in plain words
Digoxin and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein-mediated renal and intestinal efflux of digoxin by nicardipine.
What to do
Measure serum digoxin concentration and monitor for toxicity when nicardipine is started or its dose changed. Reduce digoxin dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Nicardipine?
MediHelp rates the interaction as moderate. Digoxin and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine can raise serum digoxin concentrations in some patients, with a risk of digoxin toxicity such as nausea, arrhythmias and visual disturbances. The effect is variable and generally modest.
How serious is the interaction between Digoxin and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum digoxin concentration and monitor for toxicity when nicardipine is started or its dose changed. Reduce digoxin dose if levels rise.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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