Drug interactions
Digoxin + Nizatidine
Severity: Minor
Digoxin and Nizatidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nizatidine may slightly increase digoxin absorption by raising gastric pH. The effect is generally small and rarely clinically significant.
What this interaction means in plain words
Digoxin and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH may reduce acid degradation of digoxin and modestly increase its bioavailability.
What to do
No routine change is needed; check digoxin levels and signs of toxicity if therapy with nizatidine is started or stopped in patients with narrow margins.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Nizatidine?
MediHelp rates the interaction as minor. Digoxin and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nizatidine may slightly increase digoxin absorption by raising gastric pH. The effect is generally small and rarely clinically significant.
How serious is the interaction between Digoxin and Nizatidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; check digoxin levels and signs of toxicity if therapy with nizatidine is started or stopped in patients with narrow margins.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
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