Drug interactions
Digoxin + Oxaprozin
Severity: Moderate
Digoxin and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and thereby raise digoxin concentrations, with risk of digoxin toxicity, particularly in older or renally impaired patients. Effects are variable and often modest.
What this interaction means in plain words
Digoxin and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal prostaglandin-dependent perfusion lowers glomerular filtration and digoxin renal clearance.
What to do
Monitor serum digoxin concentration, renal function and potassium when starting or stopping oxaprozin. Reduce digoxin dose if levels rise or toxicity symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Oxaprozin?
MediHelp rates the interaction as moderate. Digoxin and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and thereby raise digoxin concentrations, with risk of digoxin toxicity, particularly in older or renally impaired patients. Effects are variable and often modest.
How serious is the interaction between Digoxin and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentration, renal function and potassium when starting or stopping oxaprozin. Reduce digoxin dose if levels rise or toxicity symptoms appear.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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