Drug interactions
Digoxin + Pramipexole
Severity: Minor
Digoxin and Pramipexole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are partly eliminated by renal tubular secretion, so digoxin may modestly raise pramipexole exposure. Increased dopaminergic adverse effects such as nausea, dizziness, hallucinations or somnolence may result.
What this interaction means in plain words
Digoxin and Pramipexole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Pramipexole belongs to Cardiovascular.
Why it happens
Competition for renal tubular secretion by cationic transport pathways may reduce pramipexole clearance.
What to do
No routine dose change is needed. Watch for dopaminergic adverse effects and reduce the pramipexole dose if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Frequently asked questions
Can I take Digoxin with Pramipexole?
MediHelp rates the interaction as minor. Digoxin and Pramipexole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are partly eliminated by renal tubular secretion, so digoxin may modestly raise pramipexole exposure. Increased dopaminergic adverse effects such as nausea, dizziness, hallucinations or somnolence may result.
How serious is the interaction between Digoxin and Pramipexole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for dopaminergic adverse effects and reduce the pramipexole dose if they appear.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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