Drug interactions
Digoxin + Sulindac
Severity: Moderate
Digoxin and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and may raise serum digoxin concentrations, increasing the risk of toxicity, especially in older patients or those with renal impairment. Evidence for sulindac is less consistent than for other NSAIDs.
What this interaction means in plain words
Digoxin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
Reduced renal prostaglandin-dependent perfusion lowers glomerular filtration and digoxin clearance.
What to do
Monitor serum digoxin concentration, renal function and potassium when starting or stopping the NSAID, and adjust the digoxin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Sulindac?
MediHelp rates the interaction as moderate. Digoxin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and may raise serum digoxin concentrations, increasing the risk of toxicity, especially in older patients or those with renal impairment. Evidence for sulindac is less consistent than for other NSAIDs.
How serious is the interaction between Digoxin and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentration, renal function and potassium when starting or stopping the NSAID, and adjust the digoxin dose accordingly.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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