Drug interactions
Digoxin + Sulphasalazine
Severity: Moderate
Digoxin and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral sulfasalazine has been reported to lower digoxin bioavailability, which may reduce its serum concentrations and therapeutic effect. The effect is modest and variable but could matter in patients with atrial fibrillation or heart failure who are stabilized on digoxin.
What this interaction means in plain words
Digoxin and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Reduced gastrointestinal absorption of digoxin, possibly through binding or altered intestinal handling.
What to do
Monitor heart rate and serum digoxin concentration when sulfasalazine is started or stopped. Adjust the digoxin dose if levels or response change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Sulphasalazine?
MediHelp rates the interaction as moderate. Digoxin and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral sulfasalazine has been reported to lower digoxin bioavailability, which may reduce its serum concentrations and therapeutic effect. The effect is modest and variable but could matter in patients with atrial fibrillation or heart failure who are stabilized on digoxin.
How serious is the interaction between Digoxin and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and serum digoxin concentration when sulfasalazine is started or stopped. Adjust the digoxin dose if levels or response change.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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