Drug interactions
digoxin + verapamil
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ digoxin levels → toxicity.
Mechanism of action
P-gp inhibition.
Clinical management
Reduce dose/monitor levels, ECG, and symptoms.
Drug reference
References
Frequently asked questions
Can I take digoxin with verapamil?
The interaction is rated: Major. ↑ digoxin levels → toxicity.
How serious is the interaction between digoxin and verapamil?
The interaction is rated: Major. Evidence level: High.
How is the interaction between digoxin and verapamil managed?
Reduce dose/monitor levels, ECG, and symptoms.
Why do digoxin and verapamil interact?
P-gp inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.