Drug interactions
Dihydroergotamine + Isoproterenol
Severity: Moderate
Dihydroergotamine and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine causes vasoconstriction, while isoproterenol is a beta agonist that causes vasodilation and tachycardia. The effects are largely opposing rather than synergistic, but cardiac stimulation in a patient with ergot-induced vasospasm could be harmful. The clinical evidence is limited.
What this interaction means in plain words
Dihydroergotamine and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Isoproterenol belongs to Respiratory.
Why it happens
Opposing vasoactive effects with additive cardiac stress; no established synergistic mechanism.
What to do
Monitor blood pressure, heart rate and ECG, and watch for signs of ischemia when both must be used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoproterenol
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Isoproterenol?
MediHelp rates the interaction as moderate. Dihydroergotamine and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine causes vasoconstriction, while isoproterenol is a beta agonist that causes vasodilation and tachycardia. The effects are largely opposing rather than synergistic, but cardiac stimulation in a patient with ergot-induced vasospasm could be harmful. The clinical evidence is limited.
How serious is the interaction between Dihydroergotamine and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG, and watch for signs of ischemia when both must be used.
What other medicines interact with Isoproterenol?
MediHelp also lists interactions of Isoproterenol with, for example, Adrenaline-articaine, Bisoprolol, Budesonide-formoterol. The full list is on the Isoproterenol page.
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