Drug interactions
Dihydroergotamine + Lenacapavir
Severity: Major
Dihydroergotamine and Lenacapavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may increase dihydroergotamine levels. Elevated ergot levels risk ergotism with peripheral and cerebral ischemia.
What this interaction means in plain words
Dihydroergotamine and Lenacapavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dihydroergotamine belongs to Central Nervous System; Lenacapavir belongs to Anti Virals.
Why it happens
CYP3A inhibition by lenacapavir reduces dihydroergotamine metabolism.
What to do
Avoid the combination and use a non-ergot migraine treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Lenacapavir?
MediHelp rates the interaction as major. Dihydroergotamine and Lenacapavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lenacapavir is a moderate CYP3A inhibitor and may increase dihydroergotamine levels. Elevated ergot levels risk ergotism with peripheral and cerebral ischemia.
How serious is the interaction between Dihydroergotamine and Lenacapavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-ergot migraine treatment.
What other medicines interact with Lenacapavir?
MediHelp also lists interactions of Lenacapavir with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Lenacapavir page.
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