Drug interactions
Dihydroergotamine + Loxapine
Severity: Moderate
Dihydroergotamine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic receptor activity, so rare serotonin toxicity or neuroleptic malignant syndrome has been proposed. Dihydroergotamine is also a vasoconstrictor, but there is no strong pharmacokinetic interaction with loxapine.
What this interaction means in plain words
Dihydroergotamine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic and dopaminergic receptor effects; mechanism not firmly established.
What to do
Monitor for mental status change, autonomic instability, hyperthermia, and rigidity after starting or increasing doses. Stop treatment and seek urgent care if these signs develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Loxapine?
MediHelp rates the interaction as moderate. Dihydroergotamine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic receptor activity, so rare serotonin toxicity or neuroleptic malignant syndrome has been proposed. Dihydroergotamine is also a vasoconstrictor, but there is no strong pharmacokinetic interaction with loxapine.
How serious is the interaction between Dihydroergotamine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, autonomic instability, hyperthermia, and rigidity after starting or increasing doses. Stop treatment and seek urgent care if these signs develop.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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