Drug interactions
Dihydroergotamine + Maprotiline
Severity: Moderate
Dihydroergotamine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine has serotonergic receptor activity, and with serotonin-enhancing antidepressants there is a risk of serotonin toxicity. Tricyclic-type agents may also add to vasoconstrictive or cardiovascular effects.
What this interaction means in plain words
Dihydroergotamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive serotonergic and adrenergic effects at receptor and reuptake level.
What to do
Monitor for serotonin syndrome symptoms and for excessive vasoconstriction or hypertension. Consider alternative migraine therapy if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Maprotiline?
MediHelp rates the interaction as moderate. Dihydroergotamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine has serotonergic receptor activity, and with serotonin-enhancing antidepressants there is a risk of serotonin toxicity. Tricyclic-type agents may also add to vasoconstrictive or cardiovascular effects.
How serious is the interaction between Dihydroergotamine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome symptoms and for excessive vasoconstriction or hypertension. Consider alternative migraine therapy if symptoms occur.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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