Drug interactions
Dihydroergotamine + Milnacipran
Severity: Moderate
Dihydroergotamine and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine has serotonin receptor activity, and milnacipran raises synaptic serotonin and noradrenaline. Serotonin syndrome is a possible risk, and both drugs may add to vasoconstriction or hypertension.
What this interaction means in plain words
Dihydroergotamine and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Milnacipran belongs to Central Nervous System.
Why it happens
Additive serotonergic and vasoconstrictive pharmacodynamic effects.
What to do
Monitor for serotonin syndrome and elevated blood pressure. Counsel patients to report agitation, tremor, fever or severe headache.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Milnacipran?
MediHelp rates the interaction as moderate. Dihydroergotamine and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine has serotonin receptor activity, and milnacipran raises synaptic serotonin and noradrenaline. Serotonin syndrome is a possible risk, and both drugs may add to vasoconstriction or hypertension.
How serious is the interaction between Dihydroergotamine and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome and elevated blood pressure. Counsel patients to report agitation, tremor, fever or severe headache.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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