Drug interactions
Dihydroergotamine + Nadolol
Severity: Moderate
Dihydroergotamine and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers may augment the vasoconstriction caused by ergot derivatives by blocking beta-2 mediated vasodilation. This can lead to peripheral ischemia, cold extremities or worsened hypertension.
What this interaction means in plain words
Dihydroergotamine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Nadolol belongs to Cardiovascular.
Why it happens
Blockade of beta-2 vasodilation combined with ergot alpha-adrenergic vasoconstriction.
What to do
Monitor for signs of peripheral ischemia such as cold or painful extremities. Stop dihydroergotamine if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Nadolol?
MediHelp rates the interaction as moderate. Dihydroergotamine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers may augment the vasoconstriction caused by ergot derivatives by blocking beta-2 mediated vasodilation. This can lead to peripheral ischemia, cold extremities or worsened hypertension.
How serious is the interaction between Dihydroergotamine and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of peripheral ischemia such as cold or painful extremities. Stop dihydroergotamine if they occur.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
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