Drug interactions
Dihydroergotamine + Tranylcypromine
Severity: Major
Dihydroergotamine and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine has serotonergic and vasoconstrictive activity, and combining it with an MAO inhibitor may raise the risk of serotonin toxicity and hypertensive reactions. Reports are limited but the combination is generally discouraged.
What this interaction means in plain words
Dihydroergotamine and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dihydroergotamine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibition increases synaptic serotonin and amplifies the serotonergic and vasoconstrictive effects of dihydroergotamine.
What to do
Avoid the combination and use a non-serotonergic acute migraine therapy. If unavoidable, monitor blood pressure and for serotonin syndrome features.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Tranylcypromine?
MediHelp rates the interaction as major. Dihydroergotamine and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dihydroergotamine has serotonergic and vasoconstrictive activity, and combining it with an MAO inhibitor may raise the risk of serotonin toxicity and hypertensive reactions. Reports are limited but the combination is generally discouraged.
How serious is the interaction between Dihydroergotamine and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-serotonergic acute migraine therapy. If unavoidable, monitor blood pressure and for serotonin syndrome features.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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