Drug interactions
Dihydroergotamine + Ustekinumab
Severity: Minor
Dihydroergotamine and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab may theoretically normalize cytokine-suppressed CYP3A4 activity, slightly increasing dihydroergotamine metabolism. Clinical evidence of a meaningful effect is lacking.
What this interaction means in plain words
Dihydroergotamine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dihydroergotamine belongs to Central Nervous System; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Theoretical reversal of cytokine-mediated CYP3A4 suppression.
What to do
No routine adjustment; monitor headache response when starting or stopping ustekinumab.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Ustekinumab?
MediHelp rates the interaction as minor. Dihydroergotamine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ustekinumab may theoretically normalize cytokine-suppressed CYP3A4 activity, slightly increasing dihydroergotamine metabolism. Clinical evidence of a meaningful effect is lacking.
How serious is the interaction between Dihydroergotamine and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor headache response when starting or stopping ustekinumab.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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