Drug interactions
Dihydroergotamine + Zafirlukast
Severity: Moderate
Dihydroergotamine and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast is a weak inhibitor of CYP3A4 and could raise dihydroergotamine levels. Excess dihydroergotamine can cause serious peripheral and cerebral vasospasm and ischemia, though zafirlukast is much weaker than the strong inhibitors that are contraindicated.
What this interaction means in plain words
Dihydroergotamine and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Zafirlukast belongs to Respiratory.
Why it happens
Weak inhibition of CYP3A4-mediated dihydroergotamine metabolism by zafirlukast.
What to do
Monitor for signs of ergotism such as numbness, coldness of extremities, or nausea. Consider an alternative if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Zafirlukast?
MediHelp rates the interaction as moderate. Dihydroergotamine and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zafirlukast is a weak inhibitor of CYP3A4 and could raise dihydroergotamine levels. Excess dihydroergotamine can cause serious peripheral and cerebral vasospasm and ischemia, though zafirlukast is much weaker than the strong inhibitors that are contraindicated.
How serious is the interaction between Dihydroergotamine and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of ergotism such as numbness, coldness of extremities, or nausea. Consider an alternative if symptoms develop.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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