Drug interactions
Dihydroergotamine + Ziprasidone
Severity: Moderate
Dihydroergotamine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine has serotonergic activity and ziprasidone blocks dopamine and serotonin receptors. Rarely this combination may contribute to serotonin toxicity or neuroleptic malignant syndrome, although the evidence is limited. The ergot also carries a peripheral vasoconstriction risk that is not affected by ziprasidone.
What this interaction means in plain words
Dihydroergotamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Overlapping serotonergic and dopaminergic receptor effects; the mechanism is not firmly established.
What to do
Monitor for mental status change, hyperthermia, rigidity and autonomic instability after starting or changing doses. Stop both drugs and treat if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Ziprasidone?
MediHelp rates the interaction as moderate. Dihydroergotamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine has serotonergic activity and ziprasidone blocks dopamine and serotonin receptors. Rarely this combination may contribute to serotonin toxicity or neuroleptic malignant syndrome, although the evidence is limited. The ergot also carries a peripheral vasoconstriction risk that is not affected by ziprasidone.
How serious is the interaction between Dihydroergotamine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, hyperthermia, rigidity and autonomic instability after starting or changing doses. Stop both drugs and treat if toxicity is suspected.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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