Drug interactions
Dimenhydrinate + Metoclopramide
Severity: Moderate
Dimenhydrinate and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate is a sedating, anticholinergic antihistamine, so combination with metoclopramide may increase drowsiness. Its anticholinergic effect may also counteract metoclopramide's prokinetic action.
What this interaction means in plain words
Dimenhydrinate and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression and anticholinergic antagonism of prokinetic effect.
What to do
Counsel about drowsiness and avoid driving. Avoid combining them for the same nausea indication where one agent is enough.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Metoclopramide?
MediHelp rates the interaction as moderate. Dimenhydrinate and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate is a sedating, anticholinergic antihistamine, so combination with metoclopramide may increase drowsiness. Its anticholinergic effect may also counteract metoclopramide's prokinetic action.
How serious is the interaction between Dimenhydrinate and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about drowsiness and avoid driving. Avoid combining them for the same nausea indication where one agent is enough.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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