Drug interactions
Diphenoxylate-atropine + Propofol
Severity: Moderate
Diphenoxylate-atropine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is a potent sedative-hypnotic and the opioid effect of diphenoxylate can add to its CNS and respiratory depression. This matters when a patient who has taken the antidiarrheal undergoes procedural sedation or anesthesia.
What this interaction means in plain words
Diphenoxylate-atropine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression.
What to do
Tell the anesthesia team about recent diphenoxylate use and titrate propofol carefully with continuous monitoring of oxygenation and ventilation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Propofol
Frequently asked questions
Can I take Diphenoxylate-atropine with Propofol?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol is a potent sedative-hypnotic and the opioid effect of diphenoxylate can add to its CNS and respiratory depression. This matters when a patient who has taken the antidiarrheal undergoes procedural sedation or anesthesia.
How serious is the interaction between Diphenoxylate-atropine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about recent diphenoxylate use and titrate propofol carefully with continuous monitoring of oxygenation and ventilation.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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