Drug interactions
Disopyramide + Eribulin
Severity: Major
Disopyramide and Eribulin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is a class IA antiarrhythmic with a well-known risk of QT prolongation and torsades de pointes. Eribulin adds further QT prolongation, so the combined risk of ventricular arrhythmia is increased.
What this interaction means in plain words
Disopyramide and Eribulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Eribulin belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation via potassium channel blockade and other repolarization effects.
What to do
Avoid the combination and consider an alternative antiarrhythmic. If it is unavoidable, monitor the ECG closely and keep electrolytes normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Eribulin?
MediHelp rates the interaction as major. Disopyramide and Eribulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide is a class IA antiarrhythmic with a well-known risk of QT prolongation and torsades de pointes. Eribulin adds further QT prolongation, so the combined risk of ventricular arrhythmia is increased.
How serious is the interaction between Disopyramide and Eribulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider an alternative antiarrhythmic. If it is unavoidable, monitor the ECG closely and keep electrolytes normal.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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