Drug interactions
Disopyramide + Glipizide-metformin
Severity: Moderate
Disopyramide and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide can cause significant hypoglycemia, particularly in older patients and those with renal impairment or poor nutrition. Combining it with glipizide may add to this risk.
What this interaction means in plain words
Disopyramide and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
Disopyramide may increase insulin secretion through effects on pancreatic potassium channels, adding to sulfonylurea-induced insulin release.
What to do
Monitor blood glucose, especially after starting disopyramide, and reduce the glipizide dose if hypoglycemia occurs. Counsel patients on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Glipizide-metformin?
MediHelp rates the interaction as moderate. Disopyramide and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide can cause significant hypoglycemia, particularly in older patients and those with renal impairment or poor nutrition. Combining it with glipizide may add to this risk.
How serious is the interaction between Disopyramide and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, especially after starting disopyramide, and reduce the glipizide dose if hypoglycemia occurs. Counsel patients on hypoglycemia symptoms.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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