Drug interactions
Disopyramide + Glyburide-metformin
Severity: Moderate
Disopyramide and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide can cause hypoglycemia on its own, and this can be severe in some patients, especially the elderly and those with renal impairment. Combined with a sulfonylurea such as glyburide, the risk of low blood glucose is increased.
What this interaction means in plain words
Disopyramide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Disopyramide enhances pancreatic insulin secretion, which adds to the sulfonylurea effect; the combination is pharmacodynamically additive.
What to do
Monitor blood glucose closely when starting disopyramide and teach the patient to recognise hypoglycemia symptoms. Reduce the glyburide dose if hypoglycemia occurs, or consider an alternative antiarrhythmic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Glyburide-metformin?
MediHelp rates the interaction as moderate. Disopyramide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide can cause hypoglycemia on its own, and this can be severe in some patients, especially the elderly and those with renal impairment. Combined with a sulfonylurea such as glyburide, the risk of low blood glucose is increased.
How serious is the interaction between Disopyramide and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting disopyramide and teach the patient to recognise hypoglycemia symptoms. Reduce the glyburide dose if hypoglycemia occurs, or consider an alternative antiarrhythmic.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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