Drug interactions
Disopyramide + Insulin degludec
Severity: Moderate
Disopyramide and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide can cause hypoglycemia, sometimes severe, particularly in patients with renal impairment or those taking other glucose-lowering drugs. Combined with insulin degludec, the risk of low blood glucose rises.
What this interaction means in plain words
Disopyramide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Additive hypoglycemic effect, possibly through enhanced insulin secretion; the mechanism is not fully established.
What to do
Monitor blood glucose closely, and reduce the insulin degludec dose if hypoglycemia occurs. Teach the patient to recognize hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Insulin degludec?
MediHelp rates the interaction as moderate. Disopyramide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide can cause hypoglycemia, sometimes severe, particularly in patients with renal impairment or those taking other glucose-lowering drugs. Combined with insulin degludec, the risk of low blood glucose rises.
How serious is the interaction between Disopyramide and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely, and reduce the insulin degludec dose if hypoglycemia occurs. Teach the patient to recognize hypoglycemia symptoms.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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