Drug interactions
Disopyramide + Insulin glulisine
Severity: Moderate
Disopyramide and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide can cause hypoglycemia, particularly in older patients and those with renal impairment, and may add to the effect of insulin. Episodes can be severe.
What this interaction means in plain words
Disopyramide and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Insulin glulisine belongs to Endocrine.
Why it happens
Disopyramide may increase insulin secretion through pancreatic potassium channel effects, adding to exogenous insulin.
What to do
Monitor blood glucose closely and reduce the insulin dose if hypoglycemia occurs. Take extra care in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Insulin glulisine?
MediHelp rates the interaction as moderate. Disopyramide and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide can cause hypoglycemia, particularly in older patients and those with renal impairment, and may add to the effect of insulin. Episodes can be severe.
How serious is the interaction between Disopyramide and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the insulin dose if hypoglycemia occurs. Take extra care in renal impairment.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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