Drug interactions
Disopyramide + Mavacamten
Severity: Major
Disopyramide and Mavacamten: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce myocardial contractility, so combining them raises the risk of systolic dysfunction and heart failure in patients with hypertrophic cardiomyopathy.
What this interaction means in plain words
Disopyramide and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Mavacamten belongs to Cardiovascular.
Why it happens
Additive negative inotropic effects of both drugs.
What to do
Avoid the combination. If it cannot be avoided, monitor left ventricular ejection fraction and heart failure symptoms closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Disopyramide and Mavacamten, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Mavacamten?
MediHelp rates the interaction as major. Disopyramide and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs reduce myocardial contractility, so combining them raises the risk of systolic dysfunction and heart failure in patients with hypertrophic cardiomyopathy.
How serious is the interaction between Disopyramide and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If it cannot be avoided, monitor left ventricular ejection fraction and heart failure symptoms closely.
What other medicines interact with Mavacamten?
MediHelp also lists interactions of Mavacamten with, for example, Apalutamide, Carbamazepine, Clarithromycin. The full list is on the Mavacamten page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
