Drug interactions
Disopyramide + Nifedipine
Severity: Minor
Disopyramide and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is partly cleared by CYP3A4, and nifedipine is a weak CYP3A4 substrate with little inhibitory activity, so a meaningful rise in disopyramide exposure is not expected. Both drugs have negative inotropic effects, which could matter in patients with impaired ventricular function.
What this interaction means in plain words
Disopyramide and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Disopyramide belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 competition is theoretically possible, and both drugs have additive negative inotropic effects.
What to do
Monitor blood pressure, heart rate and signs of heart failure when starting the combination in patients with reduced left ventricular function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Nifedipine?
MediHelp rates the interaction as minor. Disopyramide and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Disopyramide is partly cleared by CYP3A4, and nifedipine is a weak CYP3A4 substrate with little inhibitory activity, so a meaningful rise in disopyramide exposure is not expected. Both drugs have negative inotropic effects, which could matter in patients with impaired ventricular function.
How serious is the interaction between Disopyramide and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and signs of heart failure when starting the combination in patients with reduced left ventricular function.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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