Drug interactions
Disopyramide + Quinine
Severity: Major
Disopyramide and Quinine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both quinine and disopyramide prolong cardiac repolarization and QTc. Combined use increases the risk of torsades de pointes and other ventricular arrhythmias. Quinine is also labeled to be avoided with class Ia antiarrhythmics.
What this interaction means in plain words
Disopyramide and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation through potassium channel and sodium channel blockade.
What to do
Avoid the combination where possible and choose another antimalarial or antiarrhythmic. If unavoidable, monitor ECG and electrolytes closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Quinine?
MediHelp rates the interaction as major. Disopyramide and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both quinine and disopyramide prolong cardiac repolarization and QTc. Combined use increases the risk of torsades de pointes and other ventricular arrhythmias. Quinine is also labeled to be avoided with class Ia antiarrhythmics.
How serious is the interaction between Disopyramide and Quinine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose another antimalarial or antiarrhythmic. If unavoidable, monitor ECG and electrolytes closely.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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