Drug interactions
Disopyramide + Sofosbuvir-velpatasvir
Severity: Moderate
Disopyramide and Sofosbuvir-velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is partly metabolized by CYP3A4 and has a narrow therapeutic index with risk of QT prolongation and arrhythmia. Velpatasvir may modestly raise its levels. The effect is expected to be small.
What this interaction means in plain words
Disopyramide and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Velpatasvir may weakly inhibit CYP3A4, decreasing disopyramide metabolism.
What to do
Monitor ECG (QT interval) and disopyramide levels or clinical effect. Reduce the dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as moderate. Disopyramide and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide is partly metabolized by CYP3A4 and has a narrow therapeutic index with risk of QT prolongation and arrhythmia. Velpatasvir may modestly raise its levels. The effect is expected to be small.
How serious is the interaction between Disopyramide and Sofosbuvir-velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG (QT interval) and disopyramide levels or clinical effect. Reduce the dose if toxicity appears.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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