Drug interactions
Dobutamine + Prochlorperazine
Severity: Moderate
Dobutamine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines have alpha-blocking properties that can blunt the vasoconstrictor component of catecholamine effects and promote hypotension. Both drugs can also provoke arrhythmias in susceptible patients, though the interaction is poorly characterized.
What this interaction means in plain words
Dobutamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Prochlorperazine belongs to Central Nervous System.
Why it happens
Alpha-adrenergic blockade by prochlorperazine may oppose catecholamine effects; arrhythmia risk is additive but not well established.
What to do
Monitor blood pressure and ECG during dobutamine infusion. Adjust the infusion rate to hemodynamic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Prochlorperazine?
MediHelp rates the interaction as moderate. Dobutamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines have alpha-blocking properties that can blunt the vasoconstrictor component of catecholamine effects and promote hypotension. Both drugs can also provoke arrhythmias in susceptible patients, though the interaction is poorly characterized.
How serious is the interaction between Dobutamine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ECG during dobutamine infusion. Adjust the infusion rate to hemodynamic response.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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