Drug interactions
Docetaxel + Enzalutamide
Severity: Minor
Docetaxel and Enzalutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Docetaxel is metabolized by CYP3A4, so enzalutamide may reduce its concentrations. In practice the two are often given together in prostate cancer and no clinically meaningful change in docetaxel exposure has been established.
What this interaction means in plain words
Docetaxel and Enzalutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Docetaxel belongs to Oncology; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, which could increase docetaxel clearance.
What to do
No routine dose change is needed; monitor efficacy and neutropenia as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Docetaxel
Frequently asked questions
Can I take Docetaxel with Enzalutamide?
MediHelp rates the interaction as minor. Docetaxel and Enzalutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Docetaxel is metabolized by CYP3A4, so enzalutamide may reduce its concentrations. In practice the two are often given together in prostate cancer and no clinically meaningful change in docetaxel exposure has been established.
How serious is the interaction between Docetaxel and Enzalutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor efficacy and neutropenia as usual.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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