Drug interactions
Docetaxel + Posaconazole
Severity: Major
Docetaxel and Posaconazole: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Docetaxel is cleared by CYP3A4, and strong inhibitors such as posaconazole can raise its exposure, increasing neutropenia, mucositis and other toxicity. Docetaxel labeling advises avoiding strong CYP3A4 inhibitors.
What this interaction means in plain words
Docetaxel and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Docetaxel belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 decreases docetaxel hepatic metabolism.
What to do
Avoid concurrent use where possible; if needed, consider a docetaxel dose reduction and monitor blood counts and toxicity closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Noxafil 100 mg Gastro-resistant Tablets - SmPC sections 4.3/4.5 (class statement: CYP3A4 substrates; "Posaconazole is a potent inhibitor of CYP3A4. Co-administration of posaconazole with CYP3A4 substrates may result in large increases in exposure to CYP3A4 subst") — electronic medicines compendium (UK SmPC)
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Docetaxel
Frequently asked questions
Can I take Docetaxel with Posaconazole?
MediHelp rates the interaction as major. Docetaxel and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Docetaxel is cleared by CYP3A4, and strong inhibitors such as posaconazole can raise its exposure, increasing neutropenia, mucositis and other toxicity. Docetaxel labeling advises avoiding strong CYP3A4 inhibitors.
How serious is the interaction between Docetaxel and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if needed, consider a docetaxel dose reduction and monitor blood counts and toxicity closely.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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